Saturated hydrocarbons
Cayman Chemical 2-hydroxy StearIc AcId 10mg
A hydroxy fatty acid; has been found in humans and U. armoricana; reduces growth of EAT cells (100 μM); elevated in human joint synovial fluid after ankle fracture and in patients with Buruli ulcer disease
Cayman Chemical 3-oxo StearIc AcId 500ug
An intermediate in the dissociated (or type II) fatty acid biosynthesis that occurs in bacteria; generated following the reaction of hexadecenoyl-ACP with malonyl-ACP by the enzyme β-ketoacyl-ACP synthase II, which produces 3-oxo octadecenoyl-ACP
Medchemexpress LLC Dynole 2-24 | 1416313-72-8 | 99.1% | C24H41N3 | 100 MG
Dynole 2-24 is an indole-based dynamin GTPase inhibitor that is non-toxic and demonstrates increased potency against dynamin I and II both in vitro and in cells. It shows selectivity for dynamin I and is an active in-cell inhibitor of clathrin-mediated endocytosis.
- Indole-based dynamin GTPase inhibitor
- IC50 of 0.56 μM for dynamin I
- Non-toxic
- Increased potency against dynamin I and II in vitro and in cells
- 4.4-fold selectivity for dynamin I
- Active in-cell inhibitor of clathrin-mediated endocytosis (CME)
Medchemexpress LLC Stearic acid-PEG-Mal | 5000 (average) | 500 MG
Stearic acid-PEG-Mal (MW 5000) is a pegylated lipid reagent consisting of a stearic acid hydrophobic tail attached to an average 5,000 Da polyethylene glycol chain terminated with a maleimide group. Supplied in reagent grade for research use, the material is designed for nanoparticle or micelle formulation and for covalent attachment to thiol-containing biomolecules via maleimide-thiol chemistry.
- Maleimide terminal group for selective thiol conjugation.
- PEG chain (~5,000 Da) provides steric stabilization and solubility.
- Stearic acid tail promotes self-assembly into micelles or lipid nanoparticles.
- Reagent grade formulation intended for research use only.
- Stable when stored sealed at 4°C; in solvent store at -80°C for long term.
Medchemexpress LLC Cycloheptane-1,3-dione | 1194-18-9 | 126.16 | 1 ML
Cycloheptane-1,3-dione (Compound 1A) is an intermediate that can be used to synthesize Compound 1-1, which exhibits anticancer activity against colon cancer.
- Molecular weight: 126.16
- Formula: C7H10O2
- Appearance: Liquid
- Color: Colorless to light yellow
- Density: 1.1 g/cm3
- Purity: 99.73%
- Solubility in DMSO: ≥ 100 mg/mL (792.64 mM)
- Product format: 10 mM in 1 mL of DMSO
- Shipping: Room temperature in continental US
- Storage (pure form): -20°C for 3 years; 4°C for 2 years
- Storage (in solvent): -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Stearic acid-PEG-NHS | 90.0% | 2000 (average) | 10 MG
Stearic acid-PEG-NHS (average MW 2000) is an amphiphilic PEGylated lipid bearing an N-hydroxysuccinimide (NHS) ester. It is used as a reactive lipid for covalent conjugation to primary amines and for formulation of micelles, liposomes, and PEGylated nanoparticles in research applications.
- Reactive NHS ester for amine conjugation.
- Amphiphilic PEGylated lipid suitable for micelle and liposome formation.
- Average molecular weight 2000 provides defined PEG chain length.
- Specified reagent-grade purity for research use.
- Recommended storage under nitrogen at low temperature to preserve activity.
Medchemexpress LLC Cycloheptane-1,3-dione | 1194-18-9 | 126.16 | 1 G
Cycloheptane-1,3-dione (Compound 1A) is an intermediate that can be used to synthesize Compound 1-1, which has anticancer activity against colon cancer. It appears as a colorless to light yellow liquid.
- Intermediate for chemical synthesis
- Potential use in anticancer research
- Liquid form
- Soluble in DMSO: ≥ 100 mg/mL
Cayman Chemical 9-hydroxy StearIc AcId 10mg
A hydroxy fatty acid and an active metabolite of 9-PAHSA; inhibits HDAC1 in HT-29 cell lysates at 5 µM; inhibits proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells at 100 µM
Cayman Chemical 9-hydroxy StearIc AcId 25mg
A hydroxy fatty acid and an active metabolite of 9-PAHSA; inhibits HDAC1 in HT-29 cell lysates at 5 µM; inhibits proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells at 100 µM
Medchemexpress LLC Octadecane-1-thiol-d37 | 668433-57-6 | 98.1% | 323.79 | 1 MG
Octadecane-1-thiol-d37 is the deuterium labeled Octadecane-1-thiol. It is for research use only and not sold to patients.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Cayman Chemical 12-hydroxy StearIc AcId 10g
A hydroxy fatty acid; a low molecular weight gelator that self-assembles to form organogels; administration of paclitaxel in 12-hydroxy stearic acid-containing gel nanocarriers enhances tumor growth suppression in an H22 murine hepatocellular carcinoma model
Medchemexpress LLC TPI-287 | 849213-15-6 | 99.5% | 1 MG
TPI-287 is a blood-brain barrier-permeable microtubule stabilizer that can significantly reduce metastatic colonization of breast cancer in the brain. It has been shown to effectively reduce tumor volume and inhibit tumor growth in mouse tumor models.
- Blood-brain barrier permeable microtubule stabilizer
- Significantly reduces metastatic colonization of breast cancer in the brain
- Effectively reduces tumor volume and inhibits tumor growth
- Store at 4°C under nitrogen
- Store in solvent at -80°C for 6 months, or -20°C for 1 month, under nitrogen
- Soluble in DMSO: ≥ 100 mg/mL
Cayman Chemical StearIc AcId methyl esTR 500mg
An esterified version of the free acid which is less water soluble but more amenable for the formulation of stearate-containing diets and dietary supplements
AdipoGen 56-Aminofluorescein
Chemical. CAS 27599-63-9. Formula C20H13NO5. MW 347.32. Synthetic. Two isomers are produced by the usual synthesis. Most publications imply they are interchangeable when used for the preparation of the isothiocyanate for fluorescent labeling.
Medchemexpress LLC Bis(choline)tetrathiomolybdate | 649749-10-0 | 98.0% | 432.56 g/mol | C10H28MoN2O2S4 | 10 MG
ATN-224 (bis(choline)tetrathiomolybdate) is an orally active Cu2+/Zn2+-dependent superoxide dismutase 1 (SOD1) inhibitor used in research to modulate copper-dependent enzymatic activity and angiogenesis. It inhibits SOD1 activity in endothelial and tumor cells and has been characterized in cellular and in vivo models.
- Orally active Cu2+/Zn2+ SOD1 inhibitor with reported IC50 ~17.5 nM in endothelial cells.
- High affinity copper binder, showing selectivity against Ca, Fe, Mg, Zn, and Mn up to 1 mM.
- Inhibits proliferation of HUVEC cells (IC50 ~1.4 μM) and purified SOD1 (IC50 ~0.33 μM after 24 h).
- Time-dependent SOD1 inhibition, reaching maximal effect at ~16 hours.
- Demonstrated inhibition of angiogenesis in Matrigel plug models in mice.